Molecular Machines in protein targeting and membrane protein biogenesis
نویسنده
چکیده
1989 Ph.D. Ludwig-Maximilians-Universität München, Germany (Max Planck Institute of Biochemistry, Martinsried) 1989 1991 PostDoc Max Planck Institute for Biophysics, Frankfurt, Germany (Prof. Hartmut Michel) 1991 1993 Scientist Biomedical Centre, Uppsala, Sweden (Prof. Alwyn Jones) 1994 1999 Group Leader European Molecular Biology Laboratory (EMBL), Heidelberg, Structural Biology Programme since 2000 Full Professor BZH 2006 2009 Director BZH 2011 2013 President of the GBM
منابع مشابه
Isolation and Characterization of a New Peroxisome Deficient CHO Mutant Cell Belonging to Complementation Group 12
We searched for novel Chinese hamster ovary (CHO) cell mutants defective in peroxisome biogenesis by an improved method using peroxisome targeting sequence (PTS) of Pex3p (amino acid residues 1–40)-fused enhanced green fluorescent protein (EGFP). From mutagenized TKaEG3(1–40) cells, the wild-type CHO-K1 stably expressing rat Pex2p and of rat Pex3p(1–40)-EGFP, numerous cell colonies resistant to...
متن کاملProtein degradation within mitochondria: versatile activities of AAA proteases and other peptidases.
Cell survival depends on essential processes in mitochondria. Various proteases within these organelles regulate mitochondrial biogenesis and ensure the complete degradation of excess or damaged proteins. Many of these proteases are highly conserved and ubiquitous in eukaryotic cells. They can be assigned to three functional classes: processing peptidases, which cleave off mitochondrial targeti...
متن کاملUsing Recombinant Chlamydia Major Outer Membrane Protein (MOMP) in ELISA Diagnostic Kit
Chlamydia trachomatis is one of the main causes of Sexually Transmitted Diseases (STDs) such as prostatitis and epididymitis in men and cervicitis, endometriosis, vaginitis and ureogenital tract infections in women. Serological tests with sensitivities related to specific antigens are commonly used as routine laboratory tests for diagnosis of Chlamydia. In this research the Chlamydia Major O...
متن کاملCloning, Expression and Purification of Truncated Chlamydia Trachomatis Outer Membrane Protein 2 (Omp2) and its Application in an ELISA Assay
Background: Although a simple and direct method does not exist for the detection of chlamydial infections, there are situations in which reliable serological tests, with sensi-tivity related to a specific antigen, could be helpful. Objective: The aim of this study was to clone the first 1100 bp of the C. trachomatis outer membrane protein 2 (omp2) gene in order to prepare a recombinant protein ...
متن کاملProtein biogenesis: Chaperones for nascent polypeptides
A number of molecular chaperones have been found to interact with nascent polypeptides attached to ribosomes, allowing these protein-synthesis machines to play a key part in protein folding and targeting.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2014